The function of every cell and organism depends critically on the dynamic interactions between biological macromolecules and on their correct three-dimensional structure. Faulty interactions and misfolded structures lead to disease and aging. In IBI-7 - Structural Biochemistry, research aims to understand these interactions and to determine the three-dimensional structure of protein complexes involved in crucial cellular processes. To this end, the scientists use all available atomic-resolution structural biology methods such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, cryo-electron microscopy (cryo-EM), and simulation-based approaches, together with kinetic and thermodynamic studies. The proteins of interest to researchers are critical to the reliability of biological information processing. Their malfunction is responsible for the development and progression of aging and neurodegeneration. In parallel, novel strategies and compounds are being developed to counteract neurodegeneration and aging. The D-peptide development platform starts with lead identification and leads through validation with cell cultures and animal models to clinical research. More about us ....
Direktor: Prof. Dr. Dieter Willbold
