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Dynamical force spectroscopy

Dynamical force spectroscopy
Dynamical force spectroscopy allows measuring the mechanical properties of biological complexes by force-induced dissociation of specific bonds, for example the antibody-antigen bond can be investigated. The force sensor consists of an osmotically swollen red blood cell that is attached to a micropipette and via a microbead to the probe. By variation of the suction pressure of the pipette the stiffness of the cell can be adjusted.

Biomechanics:
Rudolf Merkel

Copyright: Forschungszentrum Jülich
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