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International Helmholtz Research School
of Biophysics and Soft Matter

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Grafik: CrystallisationOfArrestin_jpg

Crystallisation of arrestin
Arrestins are proteins, which stop signalling pathways in all G-protein coupled receptor systems. We work on the interaction of arrestin with MetaII-rhodopsin by fluorescence spectroscopy. In addition, we work on the crystallization of a cGMP sensitive ion channel which transforms the chemical signal of the visual system into an electrical potential. The figure shows a ribbon diagram of the structure of arrestin: β-strands in red, α-helix in blue and loops in yellow. Right side: N-terminal domain, left side: C-terminal domain.

Molecular Biophysics:
Joachim Granzin, Georg Büldt

Molecular Sensory Systems:
Ursula Wilden, U. Benjamin Kaupp

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