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International Helmholtz Research School
of Biophysics and Soft Matter

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IHRS BioSoft faculty members

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Dieter Willbold

Forschungszentrum Jülich and Heinrich Heine University Düsseldorf

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Protein structures and ligand interactions; function and dysfunction of proteins; focus on neurodegenerative diseases. NMR spectroscopy, X-ray crystallography, cryo-electron microscopy, computer simulations.

We have developed a therapeutic strategy for protein misfolding diseases and call it anti-prionic. For Alzheimer’s disease, we have shown proof-of-concept in four animal models and progressed through phase I clinics. The compound directly disassembles toxic Aβ oligomer prions into harmless Aβ monomers.



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