Navigation and service


Method development

  • Spring
  • Helical diffraction simulator
  • LocScale

Spring is a single-particle based helical reconstruction package developed in our laboratory to determine 3D structures of a variety of highly ordered and less ordered specimens with helical symmetry from electron micrographs.

SpringCopyright: 2018 Carsten Sachse

Helical diffraction simulator is a web server tool developed in our laboratory to display Fourier patterns of helices based on input helical symmetry parameters according to the theory formulated by Cochran, Crick and Vand in 1952.

Helical_diffraction_simulationCopyright: Carsten Sachse 2018

LocScale is density scaling (sharpening) procedure that aims to enhance interpretability of cryo-EM density maps. LocScale is a reference-based local amplitude scaling tool using prior model information to improve contrast of cryo-EM density maps.

LocScaleCopyright: Carsten Sachse 2018

Additional Information

Head of ER-C-3

Structural Biology (ER-C-3)


Prof. Dr. Carsten Sachse

Phone: +49 2461 61-2030
Fax: +49 2461 61-1448

Team assistant:
Melanie Hagen

Phone: +49 2461 61-2031
Fax: +49 2461 61-1448