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Autophagy

Autophagy (from the Greek, meaning ‘to eat oneself’) is the cell’s housekeeping mechanism to engulf and degrade long-lived proteins, macromolecular aggregates, damaged organelles and even microbes in double-membrane vesicles called autophagosomes.

In our group, we investigate the molecular structures involved in autophagy as they provide fundamental insights for our understanding of aberrant cellular processes like cancer, ageing or infection.

AutophagyCopyright: 2018 Carsten Sachse

Multiprotein complexes are essential mediators in the events leading to autophagy. On the structural level, however, little is known about their 3D architecture. Fundamental questions on the nature of these complexes need to be addressed:

  • How are protein deposits structurally linked to autophagy?
  • What are the shapes of these multiprotein assemblies at the membrane?
  • How do they give rise to the cellular structure of the autophagosome?

Additional Information

Head of ER-C-3

Structural Biology (ER-C-3)

Portrait


Prof. Dr. Carsten Sachse


Phone: +49 2461 61-2030
Fax: +49 2461 61-1448
E-Mail: c.sachse@fz-juelich.de

Team assistant:
Melanie Hagen

Phone: +49 2461 61-2031
Fax: +49 2461 61-1448
E-Mail: m.hagen@fz-juelich.de



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